Browsing by Author "Shekhar, Akshay"
Now showing items 1-5 of 5
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Computational fluid dynamics of developing avian outflow tract heart valves
Bharadwaj, Koonal N.; Spitz, Cassie; Shekhar, Akshay; Yalçın, Hüseyin Çağatay; Butcher, Jonathan T. (Springer, 2012-10)Hemodynamic forces play an important role in sculpting the embryonic heart and its valves. Alteration of blood flow patterns through the hearts of embryonic animal models lead to malformations that resemble some clinical ... -
An ex-ovo chicken embryo culture system suitable for imaging and microsurgery applications
Yalçın, Hüseyin Çağatay; Shekhar, Akshay; Rane, Ajinkya A.; Butcher, Jonathan T. (MYJoVE Corporation, 2010-10)Understanding the relationships between genetic and microenvironmental factors that drive normal and malformed embryonic development is fundamental for discovering new therapeutic strategies. Advancements in imaging ... -
Growth and hemodynamics after early embryonic aortic arch occlusion
NCBI Collaboration; Lindsey, Stephanie E.; Menon, Prahlad G.; Kowalski, William J.; Shekhar, Akshay; Yalçın, Hüseyin Çağatay; Nishimura, Nozomi (Springer, 2015-08)The majority of severe clinically significant forms of congenital heart disease (CHD) are associated with great artery lesions, including hypoplastic, double, right or interrupted aortic arch morphologies. While fetal and ... -
Hemodynamic patterning of the avian atrioventricular valve
Yalçın, Hüseyin Çağatay; Shekhar, Akshay; McQuinn, Tim C.; Butcher, Jonathan T. (Wiley, 2011-01)In this study, we develop an innovative approach to rigorously quantify the evolving hemodynamic environment of the atrioventricular (AV) canal of avian embryos. Ultrasound generated velocity profiles were imported into ... -
Two-photon microscopy-guided femtosecond-laser photoablation of avian cardiogenesis: Noninvasive creation of localized heart defects
Yalçın, Hüseyin Çağatay; Shekhar, Akshay; Nishimura, Nozomi; Rane, Ajinkya A.; Schaffer, Chris B.; Butcher, Jonathan T. (American Physiological Society, 2010-11-01)Embryonic heart formation is driven by complex feedback between genetic and hemodynamic stimuli. Clinical congenital heart defects (CHD), however, often manifest as localized microtissue malformations with no underlying ...
